Emmanuelle withdraws into a temple in Tibet, where she wants to find to her true self. She's given a mystic substance which will give her youth and allow her to enter the souls of other women. Now she sets out and searches her true love Mario from 20 years ago. When he sees young Emmanuelle, he doesn't believe it's really her, but she retells all the juicy details of her past to prove it to him.
Hunted by government agents and constantly assaulted by a cartel of vengeful thugs, an amnesiac known only as "626" searches for her true identity while protecting a teenage girl who shares her superhuman abilities; but when 626 uncovers the horrifying truth about her past, she must infiltrate enemy headquarters to expose a corporate conspiracy that threatens the free world,before she and her companion are silenced forever.